Endocrine Abstracts

Primary hyperparathyroidism (PHPT) has become more prevalent as routine screening for serum calcium became more widespread. The current prevalence of PHPT is about 0.5–1% and possibly higher. The majority of patients are asymptomatic or have relatively subtle symptoms. NIH criteria for surgery are mainly based on patient symptoms and/or signs of end-organ damage, and the majority of patients do not fulfil these criteria. However it has become apparent that patients not fu...

This presentation will look at specific samples of SCE exam questions. The rationale of the questions and the thinking behind the question writing will be explained. The background and rationale of the exam will be explained in terms of this being an ‘exit’ exam in Endocrinology and Diabetes to test clinical discernment and understanding within a practical context. It is linked with the JRCPTB specialty training curriculum, to enable a CCT to be awadred in awarded in...

For patients taking thyroxine replacement guidelines generally recommend aiming for a target TSH within the laboratory reference range. The evidence for this guidance is generally based on an extrapolation of data from patients with endogenous subclinical thyroid disease. We aimed to examine the safety of having a TSH which was either suppressed (≤0.03 mU/l), low (0.04–0.4 mU/l), ‘normal’ (0.4–4.0 mU/l) or raised (>4.0 mU/l) in a population-based ...

Some patients use liothyronine as thyroid replacement therapy as an alternative to L-thyroxine. Trials have examined the potential benefits, but there is little data looking at the relative safety of these two agents. All patients receiving thyroid replacement therapy between 1993 and 2014 in Tayside were included in a cohort study (n=34 355; 319 500 patient years of follow up). Overall 33 955 patients received only L-thyroxine, and 327 r...

Aim: We aimed to undertake a population-based approach to describing the prevalence and incidence of chronic hypoparathyroidism. There are very few reports on the epidemiology of this condition.Methods: Data linkage of all biochemistry, hospital admissions, prescribing and death records was undertaken in Tayside Scotland (population 400,000) from 1988 to 2015. Patients with at least 3 serum calcium concentrations below the reference range f...

Aim: We aimed to investigate mortality and morbidity in patients who were identified with primary hypoparathyroidism, post-surgical and non-surgical hypoparathyroidism.Methods: The patients who were previously identified with hypoparathyroidism, were linked to hospital admission dataset, renal registry, biochemistry dataset and prescribing dataset. In this study, death and 6 morbidities; cataract, circulatory system, infection, fracture, me...

Aim: We aimed to undertake a population-based approach to describing the prevalence and incidence of chronic hypoparathyroidism. There are very few reports on the epidemiology of this condition.Methods: Data linkage of all biochemistry, hospital admissions, prescribing and death records was undertaken in Tayside Scotland (population 400,000) from 1988 to 2015. Patients with at least 3 serum calcium concentrations below the reference range f...

Aim: We aimed to investigate mortality and morbidity in patients who were identified with primary hypoparathyroidism, post-surgical and non-surgical hypoparathyroidism.Methods: The patients who were previously identified with hypoparathyroidism, were linked to hospital admission dataset, renal registry, biochemistry dataset and prescribing dataset. In this study, death and 6 morbidities; cataract, circulatory system, infection, fracture, me...

Clinical Endocrinology 2015 82 136–141. DOI: 10.1111/cen.12559...

The aim of this study was to investigate seasonal variation in haemoglobin A1c (HbA1c) using a retrospective population analysis linking HbA1c values to the time of year. The study cohort included 171 442 NHS patients from Scotland, UK. Patients were divided into three groups. The ‘stable group’ were defined as having a HbA1c that varied less than the tertile either side of the mean HbA1c. The ‘high summer’ was comprised of ...